Wednesday, September 27, 2006

Activators or Stabilizers?

The Daily Transcript reports on a new study that indicates Eukaryotic transcription may occurs in bursts. Transcription factors (regulators of when a gene is "on" or "off") are often characterized as 'activators' or repressors. The paper suggests activators may instead be stabilizers. Genes are always flipping back and forth between different levels of on and off states and when transcription factors bind they can hold one state steady. When upregulation happens a gene isn't 'turned on', it is just kept on.

This paper seems to indicate that cells (at least eukaryotic cells) have varied systems to regulate transcription. Even within prokaryotic cells, the initial 'jiggly' association of RNA polymerase and the promoter seems to be stabilized by Transcription factors. Once RNAP is associated with DNA, it was very stable. Could stabilizers be 'uncoupling' the initial weak RNAP-DNA binding? Could this be related to the phenomenon of abortive transcription seen in vitro?

1 comment:

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